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UDCORE-II®

UDCORE-II Product

UDCORE-II®

Undenatured Chicken Sternum Collagen Complex II

UDCORE-II is Microcore's flagship undenatured collagen product, meticulously derived from young chicken sternum through a unique backward integration process. Our production facility adheres to the highest global standards, ensuring purity and efficacy across all batches.

ISO-22000 GMP Certified FSSAI / CL HALAL Kosher

Strategic Integration

This product is supplied only as a formulated product or finished product. It is not supplied as an independent ingredient, ensuring the integrity of the therapeutic application.

Oral Tolerance Mechanism
Bio-Mechanism Visualization

The glycosylated form of Undenatured Collagen II interacting with DCs in GALT.

The Science of Oral Tolerance

The key feature of UDCORE-II is its integrated epitope or antigenicity. Undenatured Collagen Type-II has a specific mechanism of action designed to be taken up by Dendritic Cells (DCs) in the Gut-Associated Lymphoid Tissue (GALT) in its glycosylated form.

  • T helper cells recognize the antigen epitopes, inducing an initial mild immune response.
  • Gradual development of Oral Tolerance attenuates the immune response against cartilage collagen II.
  • Stimulation of T regulatory cells suppresses T helper cell response, stopping inflammatory cartilage destruction.
Synthesis of endogenous collagen or supplementation with collagen peptides becomes effective once the immune response is adequately suppressed.

Frequently Asked Questions

Learn more about the quality and science behind our products

The sternum is a soft cartilage organ found in the central part of the chicken breast bone. Microcore selects only young chickens to ensure flexible sternum cartilage, maximizing the extraction of high-quality Collagen Type II with active, integrated epitopes.

Our Natural Chicken Sternum Collagen Complex contains a balanced profile of bioactive components:

  • Collagen Complex: 18-20%
  • Hyaluronic Acid: 12-14%
  • Chondroitin Sulfate: 30-36%
  • Glycosaminoglycans (GAGs): 20-22%

  • Collagen Complex: Above 85%
  • Undenatured Collagen Content in Complex: 40%
  • Integrated Epitope: 100%

UDCORE-II contains integrated epitopes or antigenicity. In its glycosylated form, it is taken up by Dendritic Cells (DCs) in the GALT. This triggers T helper cells to recognize the antigen epitopes, inducing an initial mild immune response that gradually develops into Oral Tolerance. This attenuates the immune response against cartilage collagen II, stimulating T regulatory cells and suppressing inflammatory cartilage destruction.

It specifically helps Rheumatoid Arthritis patients by gradually developing Oral Tolerance. This attenuates the immune response against cartilage collagen II, suppressing inflammatory destruction and making endogenous collagen synthesis or supplementation significantly more effective.

Drug Interactions: No negative reports when taken as directed.

Nutrient Depletion: No negative reports when taken as directed.

Toxicity & Adverse Reactions: None known when taken as directed. Technical specifications are available on request.

Yes. Microcore's Undenatured Collagen Type II is produced using patent-granted technologies and is certified by FSSAI/CL/DELHI, HALAL, ISO-22000, and GMP standards.