Jointcore® is a novel synergistic formula for comprehensive management of arthritis. It offers three ingredients (Natural Egg Shell Membrane (NESM)® , AKBACORE® AKKBA (Acetyl-11-keto-beta-boswellic acid (30% AKKBA) and CUMINCORE,®. AKBACORE® act via different pathways to offer symptomatic relief; reducing pain, inflammation and joint stiffness and increasing mobility. NESM works as biogenic precursor to fix the body damage of collagen, cartilage and synovial fluids. NESM also fixes the faults in the immune system to reduce cartilage destruction and helps in joint lubrication, reduces synovial effusion and synovial inflammation and increases muscle strength, Boswellin Super prevents formation of inflammatory mediators to reduce pain and inflammation and also prevents cartilage destruction.
CO Inhibitor
LO Inhibitor
Trichovitals® with Nano Natural Egg Shell Membrane (NESM) is being positioned as a revolutionary product for achieving healthy, beautiful hair. The incorporation of NESM suggests a focus on providing essential proteins like collagen, elastin, and keratin, which are vital for hair strength, elasticity, and overall health. The claim that ingestion of Trichovitals® is associated with significant improvements in hair thickness, reduction in hair breakage, and enhancement in hair growth over several weeks is promising. It suggests that regular consumption of this product may offer noticeable benefits to hair health and appearance. Additionally, emphasizing the importance of nutrition and dietary supplementation in maintaining hair health is a key aspect. While a balanced diet is crucial, dietary supplements like Trichovitals® can provide targeted nutrients that support hair growth and combat damage.Overall, Trichovitals® appears to offer a comprehensive approach to hair care by addressing both internal and external factors that influence hair health.
* Reference :- A randomized, open‑label, multicentered parallel‑group clinical study to evaluate the efficacy and safety of Joint Core TM (Natural Eggshell Membrane [MuttaiJow Complex TM] 400 mg + Akbacore TM Boswellia serrata [30% Akba] 90 mg + Cumincore TM [curcumin extract 96%] 10 mg) compared to Jointace DN TM (glucosamine 750 mg + diacerein 50 mg + methylsulfonylmethane 250 mg) in osteoarthritis patients 2022 Journal of Current Research in Scientific Medicine | Published by Wolters Kluwer Medknow jcrsm_21_22_R2_OA 10.4103/jcrsm.jcrsm_21_22
Pain Management: Pain management is much better and early with Joint Core ® as per the comparative data on PAIN VAS SCALE, WOMAC PAIN SUB SCALE, GLOBAL ASSESSMENT ON IMPROVEMENTS ON OSTEO ARTHRITIS SCORE, OMERACT-OARSI. Thus Nutraceuticals Combinations of Joint Core® has proved to be equivalent to that of the reference Drug combinations of Jointace DN in the management of Osteoarthritis patients by reducing inflammation, providing adequate pain relief and improving the patients functional capacity, without causing any major side effects or drug interactions as it is obtained from natural sources.
Creatinine Reduction: Joint Core® reduce Sr Creatinine values by 25 % from 1.1 (+/- ) 1.0 at zero day to 0.83 (+/-) 0.19 in 12 weeks.
HS-CRP Control: Joint Core® has Anti-inflammatory activity to CONTROL the HS- CRP inflammatory markers from 0 day at 7.15 (+/- ) 4.6 to 3.86 (+/- ) 2.91 in 12 weeks.
ESR Control: Joint Core® has Anti-inflammatory activity to CONTROL the ESR inflammatory markers from 0 day at 45.75 (+/- ) 32.83 to 9.0 (+/- ) 4.5 in 12 weeks.
Fibrinogen Levels: Joint Core® has Inflammatory markers: Fibrinogen Levels from 0 day at 309.29 (+/- ) 96.31 to 9.0 (+/- ) 4.5 in 12 weeks.
General Improvement: Joint Core® has shown significant improvement in Osteoarthritis patients with respect to the management of pain, reduction of inflammatory markers and functional improvement.
Natural Supplement Profile: Joint Core® , has proved to be a good natural supplement for taking care of Joint pain, joint stiffness and thereby improving the joint flexibility and mobility in Osteoarthritis patients. The Test product, Joint Core® (Natural egg shell membrane (Muttai Jow Complex® ) 400 mg + ABKACORE® Boswellia serrata (30%AKBA) 90 mg + CUMINCORE® (Curcumin extract96%) 10 mg) has shown significant improvement in Osteoarthritic patients with respect to the management of pain, reduction of inflammatory markers and functional improvement.
Conclusion: Thus, the test product Joint Core® has proved to be equivalent to that of the reference product Jointace DN in the management of Osteoarthritis patients by reducing inflammation, providing adequate pain relief and improving the patients functional capacity, without causing any major side effects or drug interactions as it is obtained from natural sources. Thus, Joint Core® , has proved to be a good natural supplement for taking care of Joint pain, joint stiffness and thereby improving the joint flexibility and mobility in Osteoarthritic patients.
The first line pharmacological therapy for Osteoarthritis consists of topical or oral non-steroidal anti-inflammatory drugs (NSAIDS) which only provide symptomatic pain relief and it is associated with serious life time risk after prolonged use. However continuous usage of NSAIDs can increase the chance of heart attack or stroke with higher doses or with long-term use. It is very uncertain that the patients are not aware about the fundamental difference between the effects on short term prescribed drugs vs. the long term prescribed drugs. Such lack of awareness makes OA patients dependent on the unethical practice or self practice of drugs and makes their life miserable over the period of time with severe damages on Liver and Kidney.
Together, these three molecules in Jointcore® offers a synergistic action in effectively controlling the progression of arthritis. During osteoarthritis, Arachidonic acid (ARA) converted into leukotrienes (LK) by 5-LOX enzyme. Leukotrienes are responsible for formation of inflammatory mediators like IL-1 , TNF , ICAM which produces pain & Inflammation. These inflammatory mediators lead to release of MMPs which increases cartilage breakdown and reduce cartilage formation leading to osteoarthritis progression.
AKBACORE® is a selective and potent inhibitor of 5-LOX enzyme. It inhibits release of inflammatory mediators and reduces pain and inflammation. AKBACORE® also inhibits MMPs and prevents cartilage degeneration. AKBACORE® also increases glycosaminoglycans (GAG) synthesis and promotes cartilage regeneration. AKBACORE® is clinically proven in osteoarthritic patients to reduce joint pain, stiffness and improve physical function and physical activity.
Joint core works by multiple mechanisms to offer relief from arthritis symptoms. It reduces pain and inflammation, reduces leaching or attacks on the cartilage, and inhibits effects of inflammatory mediators. It also lubricates the joints and helps in re-building the cartilage.
CUMINCORE® works as potent anti-inflammatory and inhibits CO (Cyclo-oxygenase) pathway and helps to boost the immune system vial several bio-mechanism as extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis.
Nano Natural Egg Shell Membrane Concentrate: It contains not only collagen and elastin but also contributes to higher keratin content. Keratin is indeed crucial for the strength and structure of hair, nails, and skin. With its combination of collagen, elastin, and enhanced keratin content, this concentrate appears to offer comprehensive support for hair health by providing essential building blocks and maintaining the structural integrity and elasticity of the hair follicles. This can contribute to stronger, healthier hair and overall improved appearance.
Ellagic Acid from Pomegranate: Known for its high concentration of ellagic acid, which has been linked to promoting hair growth by enlarging follicular size and prolonging the anagen (growing) phase of hair.
Amla extract (10% glucogalin): A powerful antioxidant and rejuvenator, believed to prevent hair loss.
Biotin: B-vitamin known for its role in promoting healthy hair, skin, and nails. It's often included in supplements for stronger hair.
Curcuminoids: Which is found in turmeric. It's claimed to reduce hair loss and thinning by possibly combating inflammation and oxidative stress, which are associated with hair problems.
Murraya koenigii: Known for strengthening hair roots, promoting hair growth, and preventing thinning and loss. It may contain nutrients beneficial for hair health.
While these ingredients support keratin content through various mechanisms.
Effects on Oral Supplementation of Nutraceuticals formulations Trichovitals® in young adults for healthy maintenance of hair growth Research J. Topical and Cosmetic Sci. 13(1): January - June, 2022
Effects of Oral Supplementation of Trichovitals® on Human Skin, Hair and Nail Physiology. Research J. Topical and Cosmetic Sci. 12(1): January - June, 2021
Application and merits of Eggshell Membrane in Cosmetics. Research J. Topical and Cosmetic Sci. 11(1): January-June, 2020