Microcore

Egg Yolk Antibodies (IgY)

What is Fermented Turmeric?

FERMENTED FOR BETTER FUNCTION

Fermented turmeric primarily improves liver function. The liver is the body's main internal detoxifying organ, filter out toxins from the foods eaten and environmental exposure. The liver works in constant communication with the stomach, pancreas, gallbladder, and the rest of the digestive system. It's responsible for storing and converting nutrients from the foods eaten for the body to utilize. It also works to ensure that blood glucose levels stay stable for the key to preventing imbalances and metabolic issues.

Fermentation breaks down complex and indigestible plant materials, while also reducing the carbohydrate and sugar content. Therefore, fermented turmeric powder is 1.5 X stronger than regular turmeric powder. A study in the International Journal of Food Science and Technology found the bioavailability of curcumin increased when it was fermented. Treatment with FT was associated with a decline in both ALT and AST levels. These reductions were apparent after 6 week of treatment and were maintained throughout the 12-week double-blind treatment period in FTP treatment groups. The declines in both ALT (alanine transaminase) and AST observed at week 12 were statistically significant compared with placebo, hence the fermented turmeric remains a best protective and preventive of the several disease associated with Liver.

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Significances

Specific IgY molecule has a structure similar to that of IgG, with two heavy chains (H), each one with a molecular weight of 67 to 70 kDa, and two light chains (L), with 25 kDa. The light chains have one constant region (CL) and one variable region (VL), similar to IgG. The major difference between IgY and IgG is found at the heavy chains. IgG has three constant regions at the heavy chains (CH1-CH3), while IgY has four constant regions (CH1-CH4) . A further constant domain, with the corresponding carbohydrate chains, gives IgY a higher molecular weight (180 kDa) in comparison to IgG (150 kDa).

Frequently Asked Questions

Specific (IgY) antibodies are a relevant alternative to use as antimicrobials in human and veterinary health in the face of the emergence of resistant bacteria.

  • Specific (IgY) molecule could be used in the prophylaxis of C. difficile infection, as well as an immunotherapeutic to eliminate the remaining spores on the intestines.
  • Specific (IgY) molecule against HP-Nap protein, the main virulence factor of H. pylori, significantly inhibited the adhesion of the bacterium to an AGS cells culture.
  • The therapeutic potential of IgY against bacterial respiratory tract infections has also been considered. IgY against Mycobacterium tuberculosis increased the proliferation of PBMC (peripheral blood mononuclear cells).
  • Specific (IgY) molecule has also been tested as a potential therapeutic resource in oral infections against Prevotella intermedia. Specific IgY inhibited bacterial growth in liquid medium and showed therapeutic activity in rats with P. intermedia induced gingivitis.
  • Specific (IgY) molecule against the bacterium Aeromonas salmonicida, the causative agent of ulcers on fish skin, was added, in powder form, to the water in which Koi carp (Cyprinus carpio koi) ornamental fish were raised.

Microcore has developed unique Green GRAS and multi stage purification technologies to produce IgY from Egg Yolk Balls.

The developments are at lab scale and expected to complete clinical studies and further launch by 2025.

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