Microcore has more than two decades of experiences in research, manufacturing and scale up of many Nutrabioceuticals and Therapeutics. Our new innovations helps us to develop unique and GRAS Green enzyme technologies for the purification of Collagen type X from Egg Shell Membrane.
Collagen Type X is a specialized, non-fibrillar collagen naturally present in the eggshell membrane (ESM). It plays a crucial role in bone and cartilage formation, particularly in the later stages of cartilage maturation.
Produced by hypertrophic chondrocytes, Type X collagen is a specialized collagen that serves as a key biomarker of cartilage maturation and endochondral ossification—the natural process through which soft cartilage is transformed into mineralized bone during skeletal growth and repair. The presence of Type X collagen in eggshell membrane offers a unique, naturally derived bioactive component with significant potential in supporting joint health, cartilage regeneration, bone remodeling, and musculoskeletal wellness. This distinctive feature makes eggshell membrane an attractive ingredient for innovative regenerative and orthopedic applications.
1. Chondrocyte Activation:Enhances the function of hypertrophic chondrocytes.
2. Matrix Mineralization:Facilitates essential calcium and phosphate deposition.
3. Structural Support:Works in synergy with Collagen I and V.
4. Inflammation Modulation:Helps reduce mediators like IL-1β and TNF-α.
The developments are at lab scale and expected to complete clinical studies and further launch by 2028.